MMAF Hydrochloride

产品编号 T16121Cas号 1415246-68-2

别名 Monomethylauristatin F Hydrochloride

MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.

MMAF Hydrochloride

产品编号 T16121别名 Monomethylauristatin F HydrochlorideCas号 1415246-68-2

规格	价格	库存
5 mg	¥ 661	1-2周
50 mg	¥ 1,990	1-2周
100 mg	¥ 2,820	1-2周

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产品介绍

生物活性

产品描述	MMAF Hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF Hydrochloride is an effective tubulin polymerization inhibitor and is used as an antitumor compound.
体外活性	MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].
体内活性	cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively. The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg) [4].
别名	Monomethylauristatin F Hydrochloride

化学信息

分子量	768.42
分子式	C₃₉H₆₆ClN₅O₈
CAS No.	1415246-68-2

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 27 mg/mL (35.14 mM), Sonication and heating are recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3014 mL	6.5069 mL	13.0137 mL	65.0686 mL
5 mM	0.2603 mL	1.3014 mL	2.6027 mL	13.0137 mL
10 mM	0.1301 mL	0.6507 mL	1.3014 mL	6.5069 mL
20 mM	0.0651 mL	0.3253 mL	0.6507 mL	3.2534 mL